Retrospective study of the efficacy and safety of metronidazole and vancomycin for Clostridioides difficile infection

Introduction According to the Japanese guidelines for management of Clostridioides difficile infection (CDI), first choice is metronidazole (MNZ) non-severe cases and vancomycin (VCM) severe cases. However, appropriateness this in patients unclear. We therefore evaluated CDI incidence adverse drug reactions. Methods The electronic chart data at Keio University Hospital between January 2012 June 2019 were retrospectively reviewed. response rate, relapse reaction rate treatment using MNZ or VCM investigated according disease severity. Factorial analysis associated with response, relapse, was also performed. Results In 352 surveyed, no significant difference observed regardless severity CDI. presence cancer a factor related persistence diarrheal symptoms older age risk relapse. induced nausea significantly more frequently than VCM, young female sex factors nausea. Conclusion As guidelines, which recommend as choice, demonstrated be appropriate. Attention suggested necessary when administering females.